Enzymatic Transamination of Pyridoxamine
نویسندگان
چکیده
منابع مشابه
The stereochemistry of enzymatic transamination.
An approach to the determination of the complete stereochemistry of enzymatic transamination is described. Stereospecificity in the enzymatic labilization of one of the 4-methylene protons of pyridoxamine has been demonstrated in the transamination of pyridoxamine catalyzed by apoglutamate-oxaloacetate transaminase. Both enantiomers of the 4-(CHD-NH2) pyridoxamine have been prepared. These comp...
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Recent research has resulted in considerable modification of the earlier concept that enzymatic transamination was limited to reactions between alanine, aspartate, glutamate, and their or-keto analogues. Reactions leading to the reversible amination of the cY-keto analogues of many of the natural amino acids have been described (l-5), and there is also evidence that aldehyde groups may particip...
متن کاملThe enzymatic oxidation of pyridoxine and pyridoxamine phosphates.
Extracts of rabbit liver and brain are known (1, 2) to oxidize pyridoxine 5-phosphate to pyridoxal 5-phosphate much faster than they oxidize free pyridoxine to pyridoxal. Comparison of the two activities during limited purification indicated that different enzymes catalyzed the two reactions (1). Pogell (3) had shown previously that oxidation of pyridoxamine 5-phosphate was catalyzed by an enzy...
متن کاملNon-enzymatic transamination with glyoxylic acid and various amino acids.
An important consideration in formulating the interconversion of keto and amino acids as a transamination involving the intermediate formation of a Schiff base is the non-enzymatic occurrence of such reactions in certain model systems (l-3). Hitherto, all non-enzymatic transaminations have been observed under grossly unphysiological conditions of temperature and pH (3-5). In studying the metabo...
متن کاملMetal Ion Dependence of the Asymmetric Transamination of Phenylpyruvic Acid by Pyridoxamine in the Presenee of ~-Cyclodextrin
Transamination reactions of phenylpyruvic acid and pyridoxamine in the presence of metal ions and ~-cyclodextrin as a ehiral auxiliary have been investigated in neutral aqueous solution. The rate and extent of the transamination, and the asymmetric induction observed in the reaction depend upon the nature of the metal ion. In particular, while Zn2+and C02+yield preferentially the aldimine compl...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)81374-6